Description
This assay uses the Luminex® 200™ platform.
Clinicians! This assay is now available for clinical diagnostics as HDF15-Clin under Laboratory Developed Tests (LDT) and fully regulated under the CLIA. For more information and to explore how this assay can enhance your diagnostic capabilities, visit our patient diagnostics webpage.
Consider this assay for a focused analysis of key human proinflammatory cytokines. The Human Cytokine Proinflammatory Focused 15-Plex Discovery Assay® Array (HDF15) measures 15 key biomarkers simultaneously from a small sample volume, including IL-1β, IL-6, IL-10, and TNFα. As a result, it serves as a valuable tool for studies on disease mechanisms and therapeutic responses.
This panel is ideal for research on chronic inflammatory diseases such as Crohn’s disease, systemic lupus erythematosus (SLE), and asthma. For instance, IL-6 and TNFα are commonly elevated in these conditions, and IL-10 plays a role in immune regulation.
Unlock critical insights into CAR-T therapy! CAR-T cell therapy, a groundbreaking treatment for certain cancers, involves re-engineering a patient’s T-cells to attack cancer cells. However, this therapy often triggers significant immune responses, including cytokine release syndrome (CRS) and other inflammatory side effects. The HDF15 assay is an essential tool for studying these effects, as it includes key biomarkers such as IL-6, a major driver of CRS, and IFNγ, a marker of T-cell activation.
By enabling simultaneous analysis of these and other proinflammatory cytokines, this panel supports researchers in understanding the dynamics of CAR-T-induced immune responses. It is particularly valuable for evaluating therapy efficacy, optimizing dosing strategies, and monitoring patients for potential adverse effects. The ability to measure both inflammatory and regulatory cytokines makes the HDF15 assay indispensable for improving CAR-T therapy safety and outcomes.
If you anticipate that your samples may have low cytokine levels, such as those from normal healthy populations, you might want to consider our High Sensitivity panel. This advanced option, in particular, is specifically designed to detect low abundance cytokines with greater precision, ensuring you capture even subtle variations in your data.
Discover the power of precision with our Human Cytokine Proinflammatory Focused 15-Plex Discovery Assay®, expertly designed for the Luminex® 200™ platform. This cutting-edge technology enables the simultaneous detection of multiple biomarkers from a minimal single sample, delivering comprehensive insights with unmatched efficiency. Streamline your research and unlock a new level of detail with our advanced multiplex assay solution.
If you expect your samples to have low cytokine levels, i.e. normal healthy populations, you may wish to inquire about a High Sensitivity panel.
Click here for information on shipping biological samples for Discovery Assays
Published Research Featuring Our HDF15:
- Kouthouridis, S., Sotra, A., Khan, Z., Alvarado, J., Raha, S., & Zhang, B. (2023). Modeling the progression of placental transport from early- to late-stage pregnancy by tuning trophoblast differentiation and vascularization. Advanced Healthcare Materials, 12(32), 2301428.
- Costello, L., Goncalves, K., Maltman, V., Barrett, N., Shah, K., Stephens, A., Dicolandrea, T., Ambrogio, I., Hodgson, E., & Przyborski, S. (2023). Development of a novel in vitro strategy to understand the impact of shaving on skin health: Combining tape strip exfoliation and human skin equivalent technology. Frontiers in Medicine, 10, 1236790.
- Bezverbnaya, K., Hammill, J. A., Cummings, D., Bojovic, B., Groisman, B., Baker, C. L., Aarts, C., Hayes, D. L., Rill, D., Xu, S. X., Bader, A. G., Helsen, C. W., & Bramson, J. L. (2023). T-cell engineered with a fully humanized B-cell maturation antigen-specific T-cell antigen coupler receptor effectively targets multiple myeloma. Cytotherapy, 25(5), 490–501.