Description
This assay uses the Luminex® 200™ platform.
Clinicians! This assay is now available for clinical diagnostics (HDSCR-Clin) under Laboratory Developed Tests (LDT) and fully regulated under the CLIA. For more information and to explore how this assay can enhance your diagnostic capabilities, visit our patient diagnostics webpage.
Consider this assay for a comprehensive assessment of 14 soluble cytokine receptors in human samples. The Human Soluble Cytokine Receptor 14-Plex Discovery Assay® Array (HDSCR14) includes key biomarkers such as sCD30, sIL-6R, and sVEGFR2, which are instrumental in studying cytokine signaling and immune modulation.
Cytokine receptors are fundamental to cytokine biology, playing critical roles in both normal physiological functions and various pathological conditions across a wide range of diseases. Many of these soluble receptors can specifically inhibit their cytokine ligands, acting as precise antagonists to modulate cytokine activity. The recognition of their role in regulating excessive inflammation and influencing immune responses has led to significant research into their potential as immunotherapeutic agents.
This panel is particularly useful for research into immune system regulation, inflammatory responses, and disease pathogenesis. For instance, sCD30 is involved in T cell activation and apoptosis, while sVEGFR2 plays a crucial role in angiogenesis and vascular function. Soluble IL-2RA serves as a key marker for T-cell activation and immune system disorders, making it a critical component in the study and management of a variety of diseases and therapeutic approaches.
With its broad coverage, this assay provides valuable insights into the roles of soluble receptors in various diseases, including autoimmune disorders, cancer, and chronic inflammatory conditions.
Click here for information on shipping biological samples for Discovery Assays
Published Research Featuring Our HDSCR14:
- Zheng, B., Keen, K. J., Fritzler, M. J., Ryerson, C. J., Wilcox, P., Whalen, B. A., Sahin, B., Yao, I., & Dunne, J. V. (2023). Circulating cytokine levels in systemic sclerosis related interstitial lung disease and idiopathic pulmonary fibrosis. Scientific Reports, 13, 6647.
- Russo, M. A., Georgius, P., Staats Pires, A., Heng, B., Allwright, M., Guennewig, B., Santarelli, D. M., Bailey, D., Fiore, N. T., Tan, V. X., Latini, A., Guillemin, G. J., & Austin, P. J. (2020). Novel immune biomarkers in complex regional pain syndrome. Journal of Neuroimmunology, 347, 577330.
- Hausburg, M. A., Bocker, J. M., Madayag, R. M., Mains, C. W., Banton, K. L., Liniewicz, T. E., Tanner II, A., Sercy, E., Bar-Or, R., Williams, J. S., Ryznar, R. J., & Bar-Or, D. (2022). Characterization of peritoneal reactive ascites collected from acute appendicitis and small bowel obstruction patients. Clinica Chimica Acta, 531, 126-136.